Oxidative Medicine and Cellular Longevity

Review Article

Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis

Table 1

Quality assessment of included studies.
Study (years)12345678910Total
Jia et al. [14]++−−++−+++7
Wan et al. [15]+−+−+NR−−++5
Wan et al. 2013 [16]++−−−NR−−+−3
Zhu et al. [17]+−+−++−−++6
Wang [18]−−+−−+−−++4
Xue [19]−−+−−+−−−+3
Zhang et al. [20]+−+−−+−−−−3
Min et al. [21]+−+−++−−−−4
Min [22]−−+−++−−−+4
Liu 2011 [23]−−+−−NR−−−+2
Wan et al. 2012 [24]+−+−−NR−−−+3
Wang [25]−+−−−+−−++4
Wang et al. [26]+−+−++−−−−4
Liu et al. 2011 [27]+++−−+−−−−4
Liu et al. 2011 [28]+−+−−+−−−−3
Zhang et al. 2013 [29]+++−−+−−−−4
Zhang et al. 2013 [30]+−+−−+−−−−3
Wan et al. 2012 [31]+++−−+−−++6
Zhou [32]−−+−−+−−++4
Wan et al. 2013 [33]+++−−+−−−−4
Tan et al. [34]+−+−−+−−−−3
Zhang et al. [35]+−−−−+−−−+3
Qin [36]−−+−−+−−++4
Zhang [37]−−+−−+−−++4
Wan et al. [38]+−+−++−−++6
1: peer-reviewed publication; 2: statements describing control of temperature; 3: randomization to treatment group; 4: allocation concealment; 5: blinded assessment of outcome; 6: avoidance of anesthetics with known notable intrinsic neuroprotective properties; 7: use of animals with relevant comorbidities; 8: sample size calculation; 9: compliance with animal welfare regulations; 10: declared any potential conflict of interest; NR: not reported.