Acute Exposure to Cigarette Smoking Followed by Myocardial Infarction Aggravates Renal Damage in an In Vivo Mouse Model

Table 1

Summary for qualitative assessment of histology sections. The MI group demonstrated swelling of the PCT cells and rare hyaline casts, identified in the tubular lumen. On the other hand, the S+MI group showed PCT dilation with thinning of the epithelial lining and swelling of the cells. MI and S+MI groups showed prominent focal loss of the brush border of PCTs. A total of 10 fields were screened per slide, 5 slides per mouse and 5 mice per group. The overall assessment was denoted as (+) for mild, (++) for moderate, and (+++) for severe.

	Ctrl	S	MI	S+MI
Glomerular retraction	−	+	−	+
Interstitium
Dilation of PCTs	−	++	++	++
Interstitium
(i) Thinning of PCT lining	−	−	++	+++
(ii) Focal loss of brush border
(iii) Swelling of PCT cells
Vessels
(i) Subintimal fibrosis	−	−	−	−
(ii) Vasculitis