Tubulin Beta-3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study

Table 2

List of proteins significantly upregulated in elderly versus young cells (iTRAQ ratio 117/113). Statistically significant iTRAQ ratios ( value ratio and value sample ≤ 0.05) for the 18 proteins that are upregulated.

Accession/variants	ID	Description	Gene	Peptide count	Spectral count	Sequence; coverage (%)	Ratio [elderly/young]	value ratio	value sample	Log10 ratio
P26373	RL13_HUMAN	60S ribosomal protein L13	RPL13	4	15	4.27	1.455	2.54E−03	3.04E−02	0.163
P01861	IGHG4_HUMAN	Ig gamma-4 chain C region	IGHG4	1	4	4.89	1.482	2.00E−02	2.46E−02	0.171
Q13200	PSMD2_HUMAN	26S proteasome non-ATPase regulatory; subunit 2	PSMD2	1	5	1.65	1.511	4.13E−02	1.96E−02	0.179
P13797	PLST_HUMAN	Plastin-3	PLS3	5	13	1.90	1.584	2.13E−02	1.08E−02	0.200
P49721	PSB2_HUMAN	Proteasome subunit beta type-2	PSMB2	1	22	5.47	1.635	1.82E−03	7.01E−03	0.214
P48643	TCPE_HUMAN	T-complex protein 1 subunit epsilon	CCT5	6	35	1.29	1.696	2.17E−03	4.15E−03	0.229
P11166	GTR1_HUMAN	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	4	46	2.03	1.891	2.60E−02	7.28E−04	0.277
P61158	ARP3_HUMAN	Actin-related protein 3	ACTR3	6	26	2.63	2.040	3.21E−02	1.84E−04	0.310
P09211	GSTP1_HUMAN	Glutathione S-transferase P	GSTP1	10	117	7.62	2.308	3.65E−02	1.47E−05	0.363
P78417	GSTO1_HUMAN	Glutathione S-transferase omega-1	GSTO1	4	25	5.81	2.482	2.89E−10	2.77E−06	0.395
P13667	PDIA4_HUMAN	Protein disulfide-isomerase A4	PDIA4	3	4	1.09	2.633	2.99E−02	6.60E−07	0.420
P62277	RS13_HUMAN	40S ribosomal protein S13	RPS13	1	1	7.95	2.638	2.88E−02	6.27E−07	0.421
Q13509	TBB3_HUMAN	Tubulin beta-3 chain	TUBB3	4	19	4.00	2.664	4.21E−04	4.87E−07	0.426
P30048	PRDX3_HUMAN	Thioredoxin-dependent peroxide reductase, mitochondrial	PRDX3	1	1	5.47	2.769	3.86E−02	1.80E−07	0.442
Q01813-[2]	PFKAP_HUMAN	ATP-dependent 6-phosphofructokinase,; platelet type	PFKP	2	3	2.68	3.116	3.23E−02	6.75E−09	0.494
P50213	IDH3A_HUMAN	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	3	3	2.19	3.239	6.67E−03	2.14E−09	0.510
Q9Y6N5	SQRD_HUMAN	Sulfide:quinone oxidoreductase, mitochondrial	SQRDL	1	2	2.22	3.487	8.97E−03	2.17E−10	0.543
P38606-[2]	VATA_HUMAN	V-type proton ATPase catalytic subunit A	ATP6V1A	2	2	2.43	4.833	1.38E−02	1.75E−15	0.684