Research Article
β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment
Figure 2
Quantitation of state 3 mitochondrial respiration in BNF-treated wild-type and knockout mice. State 3 respiration capacity was measured in mouse liver mitochondria isolated from BNF- and resveratrol-treated wild-type (a), Cyp1a1/1a2(−/−) (b), and triple Cyp1a1/1a2/1b1(−/−) (c) knockout mice ( each) along with nontreated control mice as in Figure 1. Changes in % ATP-linked OCR (d) were measured using XF24 metabolic analyzer. Values are presented as means ± SEM of at least 4 independent measurements for each mouse. versus respective wild-type control, BNF, and resveratrol treatment.
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