Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway

Figure 3

Mild H₂O₂ (10 μM, 12 hr) or hyperoxia (95% O₂/5% CO₂, 6 hr for endothelial cells and 90 min for mice) stimulates kallistatin, eNOS, and HIF-1 synthesis in endothelial cells and in the kidney of mice. versus control group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)