Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway

Figure 5

Signaling pathways mediated by high or mild oxygen on kallistatin regulation. High oxygen through ROS generation stimulates JNK/FOXO1 signaling activation, leading to kallistatin inhibition; mild oxygen/hyperoxia through PKC activation stimulates kallistatin-mediated HIF-1 and eNOS synthesis in endothelial cells.