Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model

Table 1

List of top 25 up- and downregulated genes in 12-month-old C3-deficient mice. Genes are ranked according to the expression fold difference—the gene from the top of the list is the most upregulated and the gene from the bottom of the list is the most downregulated in C3-deficient mice compared to control animals.

Direction in C3-def	Gene symbol	Gene name	Probe ID	Entrez Gene ID	Fold change
Up	Serpine3	Serpin peptidase inhibitor, clade E (nexin, plasminogen inhibitor)	17301155	319433	8.13
Up	Akr1e1	Aldo-keto reductase family 1, member E1	17290301	56043	4.41
Up	Edv	Endogenous sequence related to the Duplan murine retrovirus	17548311	13623	4.28
Up	Rpl29	Ribosomal protein 29	17521204	19944	4.23
Up	Abhd14a	Abhydrolase domain containing 14A	17530686	68644	4.02
Up	Gatc	Glutamyl-tRNA (Gln) amidotransferase, subunit C homolog	17451721	384281	3.70
Up	Cplx4	Complexin 4	17355086	225644	3.33
Up	Uprt	Uracil phosphoribosylotransferase (FUR1) homolog	17537003	331487	3.07
Up	H2-T22	Histocompatibility 2, T region locus 22	17344593	15039	3.02
Up	Mzt1	Mitotic spindle organizing protein 1	17309065	76789	3.01
Up	Mpc1	Mitochondrial pyruvate carrier 1	17284037	55951	2.81
Up	Adam4	A disintegrin and metallopeptidase domain 4	17282343	11498	2.78
Up	Rab6b	RAB6B, member RAS oncogene family	17520922	270192	2.75
Up	Pcdhb18	Protocadherin beta 18	17349930	93889	2.67
Up	Cdh12	Cadherin 12	17310550	215654	2.65
Up	Fabp4	Fatty acid-binding protein 4, adipocyte	17404091	11770	2.59
Up	Pde6c	Phosphodiesterase 6C, cGMP specific, cone, alpha prime	17359118	110855	2.59
Up	Fam213a	Family with sequence similarity 213, member A	17305221	70564	2.59
Up	Nefl	Neurofilament, light peptide	17301582	18039	2.57
Up	Akap6	A kinase (PRKA) anchor protein 6	17275436	238161	2.57
Up	Aldh1a1	Aldehyde dehydrogenase family 1, subfamily A1	17358103	11668	2.55
Up	Hdac1	Histone deacytelase 1	17430397	433759	2.55
Up	Rpgrip1	Retinitis pigmentosa Gtpase regulator-interacting protein 1	17299715	77945	2.54
Up	Rgs9bp	Regulator of G protein signaling 9 binding protein	17489809	243923	2.50
Down	Il1f9	Interleukin 1 family, member 9	17367652	215257	−5.53
Down	Igkv1-110	Immunoglobulin kappa variable 1-110	17459338	381777	−5.64
Down	Muc5b	Mucin 5, subtype B, tracheobronchial	17485098	74180	−6.06
Down	Krt10	Keratin 10	17269064	16661	−6.11
Down	Krtdap	Keratinocyte differentiation-associated protein	17476557	64661	−6.39
Down	Sprr2f	Small proline-rich protein 2F	17399876	20760	−6.46
Down	Ighg1	Immunoglobulin heavy constant gamma 1 (G1m marker)	17284339	16017	−6.48
Down	Ighj3	Immunoglobulin heavy joining 3	17284356	777655	−7.50
Down	Ighg2b	Immunoglobulin heavy constant gamma 2B	17284334	16016	−7.73
Down	Igkj1	Immunoglobulin kappa joining 1	17459415	110759	−8.18
Down	Defb6	Defensin beta 6	17499602	116746	−8.34
Down	Igj	Immunoglobulin joining chain	17449447	16069	−8.53
Down	Cryba4	Crystalline, beta A4	17451195	12959	−8.55
Down	Ltf	Lactotransferrin	17522555	17002	−8.70
Down	Cnfn	Cornifelin	17487919	72383	−8.97
Down	Ighj1	Immunoglobulin heavy joining 1	17284360	777648	−10.53
Down	Klk13	Kallikrein-related peptidase 13	17477191	626834	−10.71
Down	Lgsn	Lengsin, lens protein with glutamate synthetase domain	17211533	266744	−11.56
Down	Lce1c	Late cornified envelope 1C	17399899	73719	−12.31
Down	Igh-VJ558	Immunoglobulin heavy chain (J558 family)	17284314	16061	−13.62
Down	Rps13	Ribosomal protein S13	17493182	68052	−14.76
Down	Igkv4-53	Immunoglobulin kappa variable 4-53	17459423	546213	−16.50
Down	Ighj4	Immunoglobulin heavy joining 4	17284354	777656	−18.58
Down	Ppbp	Proplatelet basic protein	17438963	57349	−21.02
Down	Reg3g	Regenerating islet-derived 3 gamma	17467973	19695	−25.95