Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2

Figure 7

Possible mechanisms for SFN prevention of Ang II-induced testicular apoptotic cell death. Ang II-induced oxidative stress, inflammation, and ER stress contribute to testicular apoptotic cell death. The increased oxidative stress activated NRF2 and the transcription of its downstream target genes Ho1 and Nqo1, as an adaptive mechanism for defence. Ang II-induced testicular damage could further be alleviated by SFN, via the activation of the NRF2 antioxidant signalling.