Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells

Figure 2

RC enhances neurite outgrowth in Aβ-damaged neurons. Rat hippocampal neurons were stimulated with 5 μM Aβ for 24 h after 1 h of exposure to 0.5 μM RC. Neuronal integrity was assessed by β-III tubulin immunocytochemistry (a) and image analysis (b). Note that all images were acquired at the same magnification. Scale bar, 10 μm. (c) Total length of axons and minor neurites were quantified by NeuronJ software. Data are represented as mean ± SEM (). One-way ANOVA (post hoc Dunnett’s test) was used to determine the significance of the data. ^### versus control; and versus Aβ.

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