Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway

<div>Hederagenin inhibits the growth of cisplatin-resistant HNC cell tumor xenografts. (a, b) Growth and weight of HN9-cisR tumors in nude mice. The mice received intraperitoneal injections of the vehicle control (NT) or 50, 100, or 200 mg/kg hederagenin. (c) Comparison of daily food intake among different treatment groups. (d) Cellular GSH levels in tumors treated with vehicle or hederagenin. (e) TUNEL-positive apoptotic bodies in 10 randomly selected high-power fields were counted in a blinded manner. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway 