|
Antioxidant | Model (administration route) | Therapeutic effects | Reference |
|
NAC | Rat AF cells (in vitro supplementation) | Suppressing catabolic and proinflammatory phenotype induced by H2O2 | [14] |
Rat discs (oral administration) | Delaying IDD process induced by disc puncture | [14] |
Human NP cells (in vitro supplementation) | Retarding premature senescence induced by H2O2 | [15] |
Rabbit AF cells (in vitro supplementation) | Restraining apoptosis induced by local anesthetics | [23] |
Rat NP cells (in vitro supplementation) | Suppressing excessive autophagy induced by serum deprivation | [24] |
Rat NP cells (in vitro supplementation) | Suppressing excessive autophagy induced by compression | [25] |
|
Resveratrol | Human NP cells (in vitro supplementation) | Suppressing apoptosis | [26, 27] |
Bovine NP cells (in vitro supplementation) | Inhibiting matrix catabolic phenotype and promoting matrix anabolism | [28] |
Mouse discs (oral administration) | Delaying IDD process induced by disc puncture | [29] |
Human NP cells (in vitro supplementation) | Inhibiting matrix catabolic phenotype and promoting matrix anabolism | [30] |
Rat NP cells (in vitro supplementation) | Inhibiting apoptosis induced by IL-1 | [31] |
Human NP cells (in vitro supplementation) | Suppressing matrix catabolic phenotype induced by TNF- | [32] |
Human NP cells (in vitro supplementation) | Suppressing proinflammatory phenotype induced by IL-1 | [33] |
|
EGCG | Human NP cells (in vitro supplementation) | Retarding premature senescence induced by H2O2 | [34] |
Human NP cells (in vitro supplementation) | Suppressing the proinflammatory and catabolic phenotype induced IL-1 | [35] |
|
Fullerol | Human NP cells (in vitro supplementation) | Retarding matrix catabolism induced by H2O2 | [36] |
Rabbit discs (intradiscal injection) | Delaying IDD process induced by disc puncture |
|
Cordycepin | Rat NP cells (in vitro supplementation) | Suppressing matrix catabolic phenotype induced by LPS | [37] |
Rat organ cultured discs (ex vivo supplementation) | Delaying IDD process induced by LPS |
|
BMP7 | Human NP cells (in vitro supplementation) | Suppressing apoptosis and matrix catabolic phenotype induced by H2O2 | [38] |
IGF1 | Human AF cells (in vitro supplementation) | Retarding premature senescence induced by H2O2 | [39] |
HGF | Rabbit NP cells (in vitro supplementation) | Suppressing apoptosis and matrix catabolic and proinflammatory phenotype induced by H2O2 | [40] |
PQQ | Rat NP cells (in vitro supplementation) | Suppressing apoptosis and matrix catabolic phenotype induced by H2O2 | [41] |
Ferulic acid | Rabbit NP cells (in vitro supplementation) | Restraining apoptosis and matrix catabolic phenotype by H2O2 | [42, 43] |
GSH | Human NP cells (in vitro supplementation) | Suppressing apoptosis and matrix catabolic phenotype induced by H2O2 | [44] |
|