Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells

Figure 3

The mean BCRP, LRP, MDR1, and MRP1 gene expression level in the cell lines CCRF/CEM, CEM/C1, HL-60, HL-60/MX1, and HL-60/MX2 after 24 h exposition on: coumarin (a), coumarin with mitoxantrone (b), furanocoumarins (c), and furanocoumarins without mitoxantrone (d) derivatives.

(a)

(b)

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(d)