Research Article
Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells
Table 1
IC10 values for line cells CEM/C1, CCRF/CEM, HL-60, HL-60/MX1, and HL-60/MX2 (μM). SD: standard deviation.
| | CEM/C1 | CCRF/CEM | HL-60 | HL-60/MX1 | HL-60/MX2 | | IC10 ± SD | IC10 ± SD | IC10 ± SD | IC10 ± SD | IC10 ± SD |
| | ISO | 13.0 ± 2.5 | 6.9 ± 1.0 | 4.6 ± 0.6 | 13.8 ± 2.2 | 16.4 ± 2.1 | | BER | 12.1 ± 2.0 | 8.8 ± 1.7 | 4.6 ± 1.1 | 15.8 ± 2.6 | 11.4 ± 2.4 | | XOL | 11.7 ± 3.1 | 7.6 ± 1.0 | 4.6 ± 1.1 | 13.4 ± 2.0 | 11.1 ± 2.5 | | XIN | 12.8 ± 2.1 | 5.7 ± 3.6 | 9.3 ± 3.1 | 11.7 ± 2.6 | 10.5 ± 2.0 | | BIN | 15.5 ± 2.6 | 8.5 ± 3.1 | 4.6 ± 2.6 | 3.0 ± 2.5 | 12.9 ± 1.7 | | BOL | 15.5 ± 2.5 | 6.4 ± 2.0 | 9.2 ± 2.5 | 11.5 ± 2.5 | 10.5 ± 1.0 | | HEC | 12.7 ± 2.5 | 6.0 ± 3.1 | 9.2 ± 2.0 | 15.0 ± 3.2 | 18.2 ± 2.0 | | FEL | 21.4 ± 3.5 | 5.9 ± 0.4 | 9.8 ± 3.1 | 14.5 ± 2.8 | 16.4 ± 2.0 | | HER | 4.4 ± 1.2 | 4.3 ± 1.2 | 3.4 ± 1.9 | 18.2 ± 2.5 | 5.9 ± 0.9 | | AET | 4.5 ± 0.8 | 3.6 ± 2.2 | 9.0 ± 3.1 | 11.1 ± 4.4 | 5.9 ± 1.5 | | DHD | 5.3 ± 0.6 | 5.0 ± 1.5 | 4.8 ± 1.0 | 4.0 ± 4.3 | 5.9 ± 1.1 | | COU | 5.3 ± 0.5 | 1.0 ± 3.1 | 5.0 ± 1.5 | 4.0 ± 4.2 | 4.3 ± 2.0 | | AEL | 4.2 ± 1.1 | 4.2 ± 0.5 | 5.9 ± 4.2 | 2.5 ± 3.5 | 8.3 ± 1.1 | | UMB | 5.0 ± 0.6 | 4.0 ± 1.1 | 5.5 ± 1.5 | 13.3 ± 2.2 | 8.3 ± 1.0 | | 4,7M | 3.6 ± 0.2 | 5.5 ± 0.5 | 2.3 ± 1.1 | 16.7 ± 2.8 | 6.7 ± 1.5 | | 4,7E | 1.9 ± 1.0 | 4.5 ± 0.8 | 1.7 ± 1.6 | 16.7 ± 2.6 | 7.7 ± 1.4 | | 7ME | 2.8 ± 1.0 | 3.6 ± 1.1 | 7.7 ± 2.1 | 14.3 ± 4.2 | 8.3 ± 1.6 | | 6ME | 2.6 ± 1.0 | 5.9 ± 2.1 | 6.2 ± 2.0 | 18.2 ± 3.8 | 5.5 ± 1.6 | | 0,0D | 2.6 ± 0.3 | 4.3 ± 1.4 | 2.9 ± 0.8 | 11.1 ± 3.4 | 8.3 ± 2.2 | | SCO | 2.7 ± 0.5 | 6.2 ± 0.7 | 3.6 ± 0.3 | 22.2 ± 3.2 | 7.1 ± 1.9 |
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