Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells

Table 3

IC50 values for line cells CEM/C1, CCRF/CEM, HL-60, HL-60/MX1, and HL-60/MX2 (μM). SD: standard deviation.

	CEM/C1	CCRF/CEM	HL-60	HL-60/MX1	HL-60/MX2
	IC50 ± SD	IC50 ± SD	IC50 ± SD	IC50 ± SD	IC50 ± SD
ISO	21.5 ± 4.5	10.0 ± 4.2	21.5 ± 2.5	21.0 ± 4.2	26.0 ± 5.7
BER	28.5 ± 7.5	15.5 ± 4.5	16.5 ± 3.6	16.0 ± 4.9	36.5 ± 3.6
XOL	15.5 ± 4.5	12.5 ± 4.5	28.0 ± 5.0	19.0 ± 6.1	45.0 ± 9.0
XIN	24.0 ± 5.0	23.0 ± 7.6	61.0 ± 7..0	36.0 ± 5.1	46.5 ± 5.5
BIN	13.0 ± 4.5	5.5 ± 4.5	22.0 ± 3.6	8.0 ± 1.0	29.0 ± 4.0
BOL	19.0 ± 4.0	15.5 ± 4.0	43.0 ± 6.1	19.5 ± 2.6	34.5 ± 5.5
HEC	22.0 ± 5.3	18.0 ± 4.2	45.0 ± 10.1	18.0 ± 6.4	29.5 ± 5.0
FEL	8.0 ± 4.0	15.5 ± 4.5	42.0 ± 5.0	31.0 ± 8.0	40.5 ± 4.5
HER	25.0 ± 4.0	25.0 ± 4.0	25.0 ± 4.6	56.6 ± 4.1	30.0 ± 4.0
AET	25.0 ± 3.5	20.0 ± 2.6	25.0 ± 3.6	67.6 ± 7.7	30.0 ± 6.5
DHD	25.0 ± 4.0	20.0 ± 2.5	20.0 ± 3.2	47.2 ± 5.5	30.0 ± 4.6
COU	25.0 ± 5.0	30.0 ± 4.7	20.0 ± 3.0	43.8 ± 4.9	40.0 ± 4.9
AEL	25.0 ± 6.6	25.0 ± 3.5	20.0 ± 4.2	47.2 ± 4.6	40.0 ± 6.2
UMB	25.0 ± 3.2	25.0 ± 3.3	20.0 ± 2.1	42.8 ± 4.9	40.0 ± 4.0
4,7M	30.0 ± 3.8	20.0 ± 3.6	20.0 ± 4.2	30.0 ± 3.5	30.0 ± 5.3
4,7E	10.0 ± 1.5	25.0 ± 4.6	10.0 ± 2.5	32.4 ± 3.1	40.0 ± 3.8
7ME	15.0 ± 2.6	25.0 ± 3.1	25.0 ± 4.5	36.8 ± 3.1	40.0 ± 6.2
6ME	30.0 ± 5.7	30.0 ± 4.9	25.0 ± 2.1	39.5 ± 6.7	30.0 ± 4.3
0,0D	25.0 ± 3.5	30.0 ± 3.6	25.0 ± 4.0	35.7 ± 4.2	40.0 ± 5.5
SCO	20.0 ± 4.2	30.0 ± 4.6	25.0 ± 3.5	42.8 ± 4.8	40.0 ± 3.5