Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells

Table 4

IC50 + M values for line cells CEM/C1, CCRF/CEM, HL-60, HL-60/MX1, and HL-60/MX2 (μM). SD: standard deviation. The survival of line cells after exposure to compounds at 50 μmol concentration drops to about 20%.

	CEM/C1	CCRF/CEM	HL-60	HL-60/MX1	HL-60/MX2
	IC50 ± SD	IC50 ± SD	IC50 ± SD	IC50 ± SD	IC50 ± SD
ISO	15.5 ± 4.5	10.5 ± 4.2	29.0 ± 2.5	28.0 ± 4.2	28.5 ± 5.7
BER	15.5 ± 7.5	14.0 ± 4.5	18.5 ± 3.6	24.0 ± 4.9	23.0 ± 3.6
XOL	15.5 ± 4.5	12.0 ± 4.5	42.0 ± 5.0	28.0 ± 6.1	37.5 ± 9.0
XIN	25.0 ± 5.0	16.0 ± 7.6	60.5 ± 10.0	31.0 ± 5.1	37.5 ± 5.5
BIN	13.0 ± 4.5	11.0 ± 4.5	27.0 ± 3.6	25.5 ± 4.0	23.0 ± 6.0
BOL	12.0 ± 4.0		19.0 ± 6.1	17.0 ± 2.6	30.0 ± 5.5
HEC	28.0 ± 5.3		46.5 ± 10.1	16.0 ± 6.4	36.0 ± 5.0
FEL	10.5 ± 4.0		36.0 ± 5.0	18.0 ± 8.0	42.0 ± 4.5
HER	23.2 ± 4.5	28.2 ± 4.5	28.1 ± 4.5	61.0 ± 4.5	28.2 ± 4.5
AET	23.6 ± 7.5	24.1 ± 7.5	22.6 ± 7.5	68.4 ± 7.5	29.4 ± 7.5
DHD	23.6 ± 4.5	23.2 ± 4.5	22.8 ± 4.5	52.3 ± 4.5	28.6 ± 4.5
COU	23.2 ± 5.0	34.0 ± 5.0	23.1 ± 5.0	47.8 ± 5.0	38.2 ± 5.0
AEL	24.0 ± 4.5	22.4 ± 4.5	21.4 ± 4.5	49.2 ± 4.5	38.8 ± 4.5
UMB	23.8 ± 4.0	22.6 ± 4.0	21.2 ± 4.0	44.8 ± 4.0	38.6 ± 4.0
4,7M	26.2 ± 5.3	23.6 ± 5.3	8.2 ± 5.3	34.0 ± 5.3	32.4 ± 5.3
4,7E	12.2 ± 4.0	27.6 ± 4.0	28.2 ± 4.0	34.2 ± 4.0	41.8 ± 4.0
7ME	13.8 ± 4.5	27.2 ± 4.5	27.6 ± 4.5	40.1 ± 4.5	37.6 ± 4.5
6ME	26.4 ± 7.5	34.0 ± 7.5	26.4 ± 7.5	42.0 ± 7.5	28.2 ± 7.5
0,0D	22.3 ± 4.5	32.2 ± 4.5	27.2 ± 4.5	38.2 ± 4.5	37.2 ± 4.5
SCO	18.7 ± 5.0	31.4 ± 5.0	27.4 ± 5.0	44.6 ± 5.0	36.4 ± 5.0