Mitochondrial Transfer from Wharton’s Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics

Figure 7

Graphic summary: WJMSC is capable of transferring healthy mitochondria to MERRF cybrid and reduces mtDNA mutation burden. Improved mtDNA mutation burden leads to amelioration in ROS generation, oxidative damage, and mitochondrial bioenergetics. The therapeutic effect of mitochondrial transfer also contributes to elongated network of mitochondria and apoptotic resistance.