Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Figure 6

Rapamycin treatment widened the differences in intracardiac cytokine profiles of ZL-C and ZO-C. Cartoon diagram shows the intracardiac proteins that were differentially expressed in response to both diabetes and Rapamycin treatment. Arrowhead points towards reduced expression. Direction of change in the protein is labeled. Expressions of GM-CSF, IL-2, IFN-γ, and IL-10 are reduced by both diabetes (in ZO-C) and Rapamycin treatment (in ZL-Rap) compared to ZL-C. Prolactin and Notch 2 are suppressed by Rapamycin treatment in ZO rat but increased in response to Rapamycin treatment in ZL rats. Uric acid and CINC-3 were increased by diabetes in ZO rats compared to ZL rats but suppressed by Rapamycin treatment. Decorin was suppressed by diabetes (ZL-C versus ZO-C) but increased by Rapamycin treatment in both ZL and ZO rats. Rapamycin treatment increased IL-22 only in ZL rats. IL-1α, IL-1β, B7-1 (CD-80), B7-2 (CD-86), and other molecules that were suppressed by diabetes but not modulated by Rapamycin are not shown here.