Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats
Table 1
Summary of 2D M-Mode, pulse wave, and tissue Doppler echo measurements on 14-week-old ZL-C and ZO-C and Rapamycin treated (ZL-Rap and ZO-Rap) rats. Values are mean ± SE. Numbers in parentheses are sample sizes. ZL-C versus ZO-C; ZO-C versus ZO-Rap; ZL-C versus ZL-Rap; ZL-Rap versus ZO-Rap.
Parameter
Main effect
value
ZL-C (4)
ZL-Rap (4)
ZO-C (4)
ZO-Rap (4)
PWTd, cm
Strain
0.001
0.15 ± 0.01
0.15 ± 0.00
0.20 ± 0.01
0.17 ± 0.01
Treatment
0.036
Interaction
0.036
RWT
Strain
0.050
0.41 ± 0.02
0.45 ± 0.01
0.53 ± 0.05
0.48 ± 0.04
Treatment
0.842
Interaction
0.257
LA, cm
Strain
0.018
0.27 ± 0.03
0.28 ± 0.04
0.40 ± 0.02
0.31 ± 0.01
Treatment
0.162
Interaction
0.090
E, m·s−1
Strain
0.016
1.09 ± 0.05
1.11 ± 0.06
1.26 ± 0.05
1.21 ± 0.03
Treatment
0.750
Interaction
0.480
E/E′
Strain
0.015
15.3 ± 0.7
13.8 ± 1.06
22.2 ± 0.9
15.6 ± 2.6
Treatment
0.021
Interaction
0.119
E′/A′
Strain
0.001
1.21 ± 0.02
1.15 ± 0.08
0.86 ± 0.05
1.08 ± 0.06
Treatment
0.014
Interaction
0.542
Vp
Strain
0.037
57 ± 3
67 ±
47 ± 1
61 ± 6
Treatment
0.005
Interaction
0.567
E/Vp
Strain
0.001
1.92 ± 0.17
1.65 ± 0.05
2.67 ± 0.11
2.03 ± 0.18
Treatment
0.006
Interaction
0.200
IVRT
Strain
0.002
17.8 ± 1.5
16.1 ± 1.3
23.3 ± 1.9
21.8 ± 0.8
Treatment
0.301
Interaction
0.966
MPI
Strain
0.011
0.38 ± 0.01
0.34 ± 0.01
0.45 ± 0.02
0.38 ± 0.02
Treatment
0.016
Interaction
0.373
PWTd, posterior wall thickness-diastole; RWT, relative wall thickness; LA, left atrial diameter; E, velocity of early mitral flow; E′, peak velocity of septal annulus; E/E′ index of LA filling pressure; Vp, flow propagation velocity; E/Vp, index of LV filling pressure; IVRT, isovolumic relaxation time; MPI, myocardial performance index. versus ZL-C.
