Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies

Figure 1

The mechanism of cytopathic hypoxia. The production of NO inhibits normal function of the respiratory complex IV interrupting the normal transport of electrons. O₂⁻ production is enhanced and reacts with NO inhibiting complex I normal function. NO, nitric oxide; NOS, nitric oxide synthase; ADP, adenosine diphosphate; ATP, adenosine triphosphate.