Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies

Table 1

Summary of antioxidants and their effects.

Antioxidant	Mechanism of action
GPx	H2O2 to H2O
SOD	O2^− to O2
CAT	H2O2 to H2O and O2
GSH	Antioxidant scavenger, DNA repair, cofactor for enzymes
AA	Acts against oxidation of lipids, proteins, and DNA
α-Tocopherol	Scavenger for lipid peroxidation products

GPx: glutathione peroxidase; SOD: superoxide dismutase; CAT: catalase; GSH: glutathione; AA: ascorbic acid.