Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

<div>Box plot of value of the ordinal predictors between PREDIMED score and circulating levels of Sirt4. Based on the multiple linear regression analysis with ordinal predictors, the most significant (<svg height="8.55521pt" id="M87" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 44.1999 8.55521" width="44.1999pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M545 106L524 126C493 85 467 65 455 65C438 65 427 113 405 238C448 295 498 362 543 439L533 448L478 435C453 386 423 331 398 295H395C370 404 347 448 282 448C169 448 23 309 23 153C23 54 65 -12 128 -12C203 -12 283 70 339 155H341C360 29 380 -12 411 -12C444 -12 491 11 545 106ZM333 204C265 95 210 54 169 54C137 54 113 96 113 171C113 302 191 405 252 405C301 405 318 306 333 204Z" id="g113-223"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="568" vert-adv-y="568" xpluscharwidth="7.384"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,11.017,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" 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602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480" xpluscharwidth="37.724000000000004"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,37.724,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480" xpluscharwidth="43.964"></glyph.data></g></svg>) threshold value of the PREDIMED score predicting the lowest decrease in circulating levels of Sirt4 was found at a score of 6 (<svg height="13.532pt" id="M88" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 56.8686 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Sirt4: sirtuin 4; PREDIMED: PREvención con DIeta MEDiterránea.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association 