Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

Table 5

Correlations among circulating levels of Sirt4 with demographics, anthropometric measurements, metabolic profile, metabolic indices, and HS evaluation.

Parameters	Circulating levels of Sirt4 (ng/mL)
	Simple correlation		Adjusted for BMI
	r	value	r	value
Age (years)	−0.363	0.017	−0.249	0.122
Anthropometric measurement
BMI (kg/m^2)	−0.804	<0.001	—	—
WC (cm)	−0.707	<0.001	−0.339	0.033
Metabolic profile
SBP (mmHg)	−0.512	<0.001	0.038	0.817
DBP (mmHg)	−0.318	0.038	0.075	0.645
Fasting glucose (mg/dL)	−0.369	0.015	−0.067	0.679
Insulin (μU/mL)	−0.543	<0.001	−0.147	0.366
Total cholesterol (mg/dL)	−0.522	<0.001	−0.257	0.109
HDL cholesterol (mg/dL)	0.814	<0.001	0.434	0.005
LDL cholesterol (mg/dL)	−0.642	<0.001	−0.276	0.085
Triglycerides (mg/dL)	−0.454	0.002	−0.246	0.126
ALT (U/L)	0.081	0.611	0.130	0.424
AST (U/L)	-0.015	0.926	0.041	0.801
γGT (U/L)	0.117	0.468	−0.006	0.971
Metabolic indices
HoMA-IR	−0.627	<0.001	−0.111	0.497
VAI	-0.559	<0.001	−0.329	0.038
HS evaluation
FLI	−0.762	<0.001	−0.633	<0.001

Correlations among variables were performed using Spearman’s rho correlation coefficients. Circulating levels of Sirt4 were significantly associated with BMI, WC, metabolic profile, and the metabolic indices. After adjusting for BMI, the associations between circulating levels of Sirt4 and the study variables were not significant, except for WC, HDL cholesterol, VAI, and FLI. A value in bold type denotes a significant difference (). Sirt4: sirtuin 4; BMI: body mass index; WC: waist circumference; SBP: systolic blood pressure; DBP: diastolic blood pressure; HDL: high-density lipoprotein; LDL: low-density lipoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; γGT: gamma glutamyl transferase; HoMA-IR: homeostatic model assessment-insulin resistance; VAI: visceral adiposity index; HS: hepatic steatosis; FLI: fatty liver index.