Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association
Table 8
Correlations of circulating levels of Sirt4 with PREDIMED score, total energy, and daily macronutrient/micronutrient intake.
Parameters
Circulating levels of Sirt4 (ng/mL)
Simple correlation
Adjusted for total energy (kcal)
r
value
r
value
PREDIMED score
0.820
<0.001
0.356
0.021
Total energy (kcal)
−0.818
<0.001
—
—
Protein (% of total kcal)
0.511
<0.001
0.100
0.529
INQ protein
0.742
<0.001
0.453
0.003
Carbohydrate (% of total kcal)
−0.070
0.656
−0.033
0.838
INQ carbohydrate
0.661
<0.001
0.184
0.242
Complex (% of total kcal)
0.395
0.009
0.082
0.606
Simple (% of total kcal)
−0.472
0.001
−0.133
0.477
Fat (% of total kcal)
−0.822
<0.001
−0.280
0.073
INQ Fat
0.578
<0.001
0.060
0.704
SFA (% of total kcal)
−0.730
<0.001
−0.370
0.016
MUFA (% of total kcal)
0.739
<0.001
0.138
0.384
PUFA (% of total kcal)
−0.124
0.430
0.050
0.754
n-6 PUFA (g/day)
−0.546
<0.001
−0.107
0.502
n-3 PUFA (g/day)
0.854
<0.001
0.646
<0.001
n-6/n-3 PUFAs ratio
−0.541
<0.001
0.123
0.438
Cholesterol (mg/day)
−0.336
0.028
−0.007
0.964
Fiber (g/day)
0.305
0.047
−0.026
0.872
Retinol Eq (μg/day)
0.337
0.027
−0.029
0.854
Vitamin C (mg/day)
0.825
<0.001
0.476
0.001
Vitamin D (μg/day)
0.407
0.007
0.083
0.601
Vitamin E (mg/day)
0.834
<0.001
0.329
0.034
Iron (mg/day)
0.335
0.028
0.067
0.673
Selenium (μg/day)
0.421
0.005
0.205
0.192
Zinc (mg/day)
0.505
0.001
0.020
0.900
MAI
0.833
<0.001
0.435
0.004
Correlations among variables were performed Spearman’s rho correlation coefficients. Circulating levels of Sirt4 were significantly associated with all the macronutrients/micronutrients evaluated in this study, except with carbohydrate and n-6 PUFA. After adjusting for total energy intake, the associations between circulating levels of Sirt4 and the study variables were lost, except for PREDIMED score, the consumption of fat, SFA and n-3 PUFA, and the intake of vitamins C and E. Sirt4: sirtuin 4; PREDIMED: PREvención con DIeta MEDiterránea; INQ: index of nutritional quality; SFA: saturated fatty acids; MUFA: monounsaturated fatty acids; PUFA: polyunsaturated fatty acids; MAI: Mediterranean adequacy index.
