Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

Table 9

Multiple regression analysis models (stepwise method) with the circulating levels of Sirt4 as dependent variable to estimate the predictive value of the following: (a) food items of PREDIMED questionnaire and PREDIMED score and (b) total energy intake, SFA, n-3 PUFA, vitamin C, and vitamin E.

Parameters	Multiple regression analysis
Model 1	R^2	β	t	value
PREDIMED score	0.335	0.579	4.6	<0.001
Fruits ≥3 servings/day	0.442	0.368	2.8	0.009
Variable excluded: other items of PREDIMED score
Model 2	R^2	β	t	value
n-3 PUFA	0.729	0.854	10.5	<0.001
Vitamin E	0.835	0.461	5.1	<0.001
Vitamin C	0.851	0.241	2.0	0.048
Variable excluded: total energy and SFA

Among adherence to the MD and food items (model 1) and among dietary macronutrient and micronutrient intake (model 2), circulating levels of Sirt4 were well predicted by PREDIMED score and n-3 PUFA. A value in bold type denotes a significant difference (). Sirt4: sirtuin 4; PREDIMED: PREvención con DIeta MEDiterránea; SFA: saturated fatty acids; PUFA: polyunsaturated fatty acids.