Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

Figure 2

Baicalin markedly attenuated BDL-induced fibrotic gene expression. BDL induced liver profibrotic genes at mRNA level. Real-time PCR analyses were performed for collagen I, fibronectin, alpha smooth muscle actin (SMA), and CTGF genes. BDL-induced increases in all four gene expressions and the inductions were significantly reduced by baicalin treatment. Results are mean ± S.E.M. for each group. versus control and ^# versus BDL.