Review Article
Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms—Biomarkers—Interventions, and Future Perspectives
Table 2
Acute kidney injury stratification criteria.
| | AKIN | KDIGO | | Serum creatinine | Stage | Stage | Serum creatinine | Urine output |
| | ≥0.3 mg/dL increase or increase ×1.5–2 from baseline | 1 | 1 | ×1.5–1.9 from baseline or ≥0.3 mg/dL increase | <0.5 mL/min/kg ×6–12 h | | Increase ×2-3 from baseline | 2 | 2 | ×2–2.9 from baseline | <0.5 mL/min/kg for ≥12 h | | Increase > ×3 from baseline or sCreatinine ≥4 mg/dL with acute increase of at least 0.5 mg/dL | 3 | 3 | ×3 from baseline or sCreatinine ≥4 mg/dL or renal replacement therapy or eGFR <35 mL/min/1.73m2 in patients <18 yo | <0.3 mL/min/kg for ≥24 h or anuria for ≥12 h |
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AKIN: Acute Kidney Injury Network; KDIGO: Kidney Disease: Improving Global Outcomes; GFR: glomerular filtration rate; ESKD: end-stage kidney disease.
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