Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD

Figure 5

Angiogenesis proteins expression in ARPE-19 cells after OX-LDL and Sal A treatment. ARPE-19 cells were divided into control, OX-LDL(100 mg/L), and OX-LDL (100 mg/L) + Sal A (5 μM/50 μM) groups and cultured for 48 hours. (a) Western blot showing changes in VEGF, PDGF, PEDF, and antiangiostatin in ARPE-19 cells 48 hours after treatment. (b–e) Quantitative densitometry results showing that OX-LDL increased VEGF and PDGF levels compared with the control group, while the OX-LDL + Sal A group decreased VEGF/PDGF and slightly increased antiangiostatin level compared with the OX-LDL group. There was no significant difference between each group in PEDF level. Data were expressed as mean ± SEM. versus the control group. ^## versus the OX-LDL group. ^# versus the Sal A group.

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