Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings

<div>Effects of statins on apoptotic cell death in rat kidney tissues, as assessed by TUNEL staining. (a) Representative photomicrographs of kidney tissue sections. DNA fragmentation was visualized by TUNEL staining (green). Nuclei were stained with DAPI (blue). (b) Quantitative analysis of apoptotic cell death (percentage of TUNEL-positive cells). Original magnification: ×100. Calibration bar = 100 <i>μ</i>m. 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ATO: atorvastatin; CI-AKI: contrast-induced acute kidney injury; DAPI: 4′,6-diamino-2-phenylindole; RUS: rosuvastatin; SSTN: simvastatin; TUNEL: terminal deoxynucleotidyl transferase dUTP nick-end labeling.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings 