mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress

Figure 4

mTOR inhibition alleviates oxidative stress in human gingival fibroblasts. (a) FACS analysis of reactive oxygen species (ROS) levels in low-passage hGFs and high-passage hGFs pretreated or not (control) with rapamycin after 3 or 30 days. (b) The results of real-time PCR show the mRNA expression of antioxidant components Cat, Sod2, and Prdx3 ( means , compared with the high-passage group).

(a)

(b)