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| Study (year) | Species (sex, n = experimental/control group) | Weight | Model (method) | Anesthetic | Treatment group (method to astragal sides) | Control group | Outcome index (time) | Intergroup differences |
|
| Zhang (2010) | SD rats (male, 10/10) | 220–280 g | Block LAD for 30 minutes then reflow for 120 minutes | Pentobarbital sodium (50 mg/kg, 3%) | Intravenous injection G-Rb1 (40 mg/kg) 10 minutes earlier before reperfusion | Intravenous injection isasteric and nonfunctional liquid 10 minutes earlier before reperfusion | (1) Myocardial infarct size; | (1) |
| (2) LDH | (2) |
| (3) CK | (3) |
| (4) MDA | (4) |
| (5) SOD | (5) |
| (6) HR | (6) |
| (7) RPP | (7) |
| (8) MAP | (8) |
|
| Wang (2016) | SD rats (male, 12/12) | 180–240 g | Block LAD for 30 minutes then reflow for 120 minutes | Urethane (1 ml/kg, 10%) | Intravenous injection G-Rb1 (40 mg/kg) before reperfusion | Intravenous injection nothing before reperfusion | (1) Myocardial infarct size | (1) |
| (2) Caspase-3 | (2) |
| (3) TNF-α | (3) |
|
| Chen (2012) | SD rats (male, 10/10) | 220–260 g | Block LAD for 30 minutes then reflow for 180 minutes | Ethyl ether | Intravenous injection G-Rb1 (100 mg/kg·d), once a day, for 7 days, before establishing model | Intravenous injection isasteric normal saline, once a day, for 7 days, before establishing model | (1) Myocardial infarct size | (1) |
| (2) SOD | (2) |
| (3) MDA | (3) |
| (4) NO | (4) |
|
| Leng (2015) | SD rats (male/female, 15/15) | 180–220 g | Intravenous injection isoprenaline (30 mg/kg) | Chloral hydrate (10%) | Intravenous injection G-Rb1 (20 mg/kg·d), once a day, for 5 days, before establishing model | Intravenous injection isasteric normal saline, once a day, for 5 days, before establishing model | (1) Microcirculation blood flow of heart surface | (1) |
| (2) LDH | (2) |
| (3) CK | (3) |
| (4) MDA | (4) |
| (5) SOD | (5) |
| (6) GSH | (6) |
| (7) NO | (7) |
| (8) HR | (8) |
| (9) The level of ST-segment depression | (9) |
|
| Liu (2012) | SD rats (male, 10/10) | 250–300 g | Block LAD for 30 minutes then reflow for 120 minutes | Barbital sodium (50 mg/kg) | Intravenous injection G-Rb1 (40 mg/kg) 10 minutes earlier before reperfusion | Intravenous injection isasteric normal saline 10 minutes earlier before reperfusion | (1) Myocardial infarct size | (1) |
| (2) Myocardial cell apoptosis rate | (2) |
| (3) P-Akt | (3) |
|
| Liu (2008) | SD rats (male/female, 20/20) | 200–250 g | Block LAD for 30 minutes | Pentobarbital sodium (1%) | Intravenous injection G-Rb1 (20 mg/kg·d), once a day, for 7 days, before establishing model | Intravenous injection isasteric normal saline, once a day, for 7 days, before establishing model | (1) Myocardial infarct size | (1) |
| (2) VEGF | (2) |
| (3) Microvessel density | (3) |
| (4) HR | (4) |
|
| Li (2006) | SD rats (male, 7/8) | 200–250 g | Block LAD for 30 minutes | Chloral hydrate (300 mg/kg) | Intravenous injection G-Rb1 (4 mg/kg·d), once a day, for 7 days, before establishing model | Intravenous injection isasteric normal saline, once a day, for 7 days, before establishing model | (1) Myocardial infarct size | (1) |
| (2) Left ventricular mass index | (2) |
| (3) The left ventricle section diameter | (3) |
| (4) SOD | (4) |
| (5) MDA | (5) |
| (6) HR | (6) |
|
| Zeng (2003) | Wistar rats (male/female, 5/5) | 200–250 g | Block LAD for 30 minutes then reflow for 360 minutes | Ethyl ether | Intravenous injection G-Rb1 (20 mg/kg) 10 minutes earlier before establishing model | Intravenous injection isasteric normal saline 10 minutes earlier before establishing model | (1) Myocardial apoptosis cell count | (1) |
|
| Wang (2008) | SD rats (male, 9/9) | 260–320 g | Block LAD for 45 minutes then reflow for 120 minutes | Pentobarbital sodium (80 mg/kg) | Intravenous G-Rb1 (40 mg/kg) 10 minutes earlier before reperfusion | Intravenous nothing before reperfusion | (1) Myocardial infarct size | (1) |
| (2) CK | (2) |
| (3) CK-MB | (3) |
| (4) LDH | (4) |
| (5) cTnT | (5) |
| (6) HR | (6) |
| (7) RPP | (7) |
| (8) MAP | (8) |
|
| Wu (2012) | SD rats (male, 6/6) | 250–300 g | Block LAD for 30 minutes then reflow for 120 minutes | Barbital sodium (50 mg/kg) | Intravenous G-Rb1 (40 mg/kg) 10 minutes earlier before reperfusion | Intravenous nothing before reperfusion | (1) Myocardial infarct size | (1) |
| (2) Myocardial cell apoptosis rate | (2) |
| (3) CK-MB | (3) |
| (4) LDH | (4) |
| (5) P-Akt | (5) |
| (6) Caspase-3 | (6) |
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