Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer’s Disease

Figure 9

Schematic diagram demonstrating the effects of Rg1 treatment on behavior and hippocampal proteome. On the one hand, Rg1 treatment could improve the memory impairment and ameliorate the depression-like behaviors of 3xTg-AD mice. On the other hand, proteomic analysis revealed that Rg1 could modulate the expression of multiple hippocampal proteins in 3xTg-AD mice. Notably, complexin-2 (CPLX2), a depression- and memory-related protein, and synapsin-2 (SYN2) and synaptosomal-associated protein 25 (SNP25), two memory-related proteins, were significantly downregulated in the hippocampus of 3xTg-AD mice compared with the WT mice, and the treatment of Rg1 modulated the expression of CPLX2 and SNP25 in hippocampus of 3xTg-AD mice.