Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial

Figure 2

Changes in hemodynamic variables among patients who were administered conventional mechanical ventilation with 12 mL/kg tidal volume (V_T) and 0 cm H₂O positive end-expiratory pressure (PEEP) (CV group) or protective lung ventilation with 6 mL/kg V_T and 10 cm H₂O PEEP (PV group) during surgery. Bars indicate the standard deviation. The time points for measurements were T1—just before changing the ventilation strategy following stabilization of hemodynamic parameters after intubation; T2 and T3—1 and 3 h, respectively, after changing the ventilation strategy; T4—end of surgery; and T5—immediately after extubation.

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