Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds

Table 5

Gastroprotective effect of EAMM against the pylorus ligation assay.

Pretreatment	Dose (mg/kg)	Gastric juice (mL)	pH	Free Acidity (mEq/L)	Total acidity (mEq/L)	Gastric wall mucus (Alcian blue μg/g wet tissue)
10% DMSO	—	9.67 ± 0.67	1.51 ± 0.12	1061.00 ± 205.70	1513 ± 122.30	263.10 ± 35.43
Ranitidine	100	2.30 ± 0.37	4.18 ± 0.81	243.00 ± 39.56	644.00 ± 89.61	592.60 ± 31.84
EAMM	50	13.33 ± 1.15	1.99 ± 0.17	528.00 ± 37.70	692.60 ± 95.98	404.10 ± 48.31
	250	6.75 ± 0.93	3.40 ± 0.49	319.20 ± 46.76	553.40 ± 43.89	636.90 ± 41.33
	500	5.17 ± 0.50	4.00 ± 0.27	292.10 ± 47.87	579.50 ± 38.42	659.30 ± 41.15

Data were expressed as mean ± SEM and analyzed by one-way ANOVA followed by Dunnett’s post hoc test ().
as compared to control (10% DMSO).