Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds
Table 6
Effect of EAMM on SOD, CAT, GSH, PGE2, and TBARS level in rat gastric tissues.
Pretreatment
Dose
SOD
Catalase
GSH
TBARS
PGE2
(mg/kg)
(U/mg protein)
(nmol/min/mL)
(μM/mg protein)
(μmol/mL)
(ng/mg)
Normal (untreated)
—
2.51 ± 0.07
127.60 ± 0.62
13.57 ± 0.55
0.12 ± 0.00
11.30 ± 0.67
10% DMSO
—
1.28 ± 0.04
198.21 ± 1.60
2.51 ± 0.34
0.37 ± 0.03
4.74 ± 0.25
Ranitidine
100
1.79 ± 0.04
117.80 ± 0.80
4.69 ± 0.40
0.16 ± 0.09
8.27 ± 1.01
EAMM
50
1.30 ± 0.07
104.40 ± 1.48
3.29 ± 0.36
0.22 ± 0.01
4.75 ± 0.31
250
1.71 ± 0.10
122.30 ± 1.62
5.12 ± 0.29
0.16 ± 0.08
8.37 ± 0.84
500
1.71 ± 0.12
120.30 ± 1.91
5.93 ± 0.42
0.16 ± 0.01
5.94 ± 0.61
Data were expressed as mean ± SEM and analyzed by one-way ANOVA followed by Dunnett’s post hoc test (). < 0.05 as compared to control (10% DMSO).
