Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds

Table 7

Gastroprotective effect of EAMM following pretreatment with L-NAME or NEM assessed using the ethanol-induced gastric ulcer model.

Pretreatment	Treatment	Dose (mg/kg)	Ulcer area (mm^2)
Saline	10% DMSO	—	27.68 ± 1.69
	CBXN	100	6.83 ± 0.60
	EAMM	500	1.67 ± 0.33
L-NAME	10% DMSO	—	36.67 ± 2.78
	CBXN	100	12.00 ± 0.73
	EAMM	500	8.83 ± 0.60
NEM	10% DMSO	—	41.67 ± 1.75
	CBXN	100	18.50 ± 2.26
	EAMM	500	11.25 ± 0.54

Data were expressed as mean ± SEM and analyzed by one-way ANOVA followed by Dunnett’s post hoc test ().
as compared to control (saline + 10% DMSO).
as compared to control (L-NAME + 10% DMSO).
as compared to control (saline + CBXN).
as compared to control (saline + EAMM).
as compared to control (NEM + 10% DMSO).