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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 6572714, 13 pages
https://doi.org/10.1155/2017/6572714
Research Article

Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3

1Nove de Julho University, São Paulo, SP, Brazil
2Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), School of Medical Sciences of São José dos Campos Humanitas and Universidade Brasil, São Paulo, SP, Brazil
3Institute of Physical Activity Sciences and Sports, Post-Graduate Program in Human Movement Sciences, Cruzeiro do Sul University, São Paulo, SP, Brazil
4Institute for Memory Impairments and Neurological Disorders (MIND Institute), University of California, Irvine, CA, USA
5Laboratory of Experimental Therapeutics (LIM 20), Department of Medicine, School of Medicine, University of Sao Paulo, São Paulo, SP, Brazil
6Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK

Correspondence should be addressed to Rodolfo Paula Vieira; rb.moc.oohay@anelerdor

Received 19 May 2017; Revised 9 August 2017; Accepted 29 August 2017; Published 18 October 2017

Academic Editor: Julien S. Baker

Copyright © 2017 Maysa Alves Rodrigues Brandao-Rangel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “From the global strategy for the diagnosis, management and prevention of COPD, global initiative for chronic obstructive lung disease (GOLD),” 2017, http://goldcopd.org.
  2. P. Laveneziana and P. Palange, “Physical activity, nutritional status and systemic inflammation in COPD,” The European Respiratory Journal, vol. 40, no. 3, pp. 522–529, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Yew-Booth, M. A. Birrell, M. S. Lau et al., “JAK-STAT pathway activation in COPD,” The European Respiratory Journal, vol. 46, no. 3, pp. 843–845, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Garcia-Aymerich, P. Lange, M. Benet, P. Schnohr, and J. M. Antó, “Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: a population-based cohort study,” American Journal of Respiratory and Critical Care Medicine, vol. 175, pp. 458–463, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. C. Toledo, R. M. Magalhaes, D. C. Hizume et al., “Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke,” The European Respiratory Journal, vol. 39, no. 2, pp. 254–264, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. B. T. Menegali, R. T. Nesi, P. S. Souza et al., “The effects of physical exercise on the cigarette smoke-induced pulmonary oxidative response,” Pulmonary Pharmacology & Therapeutics, vol. 22, pp. 567–573, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. R. P. Vieira, R. C. Claudino, A. C. S. Duarte et al., “Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice,” American Journal of Respiratory and Critical Care Medicine, vol. 176, pp. 871–877, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. R. P. Vieira, V. F. de Andrade, A. C. S. Duarte et al., “Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling,” American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 295, pp. L670–L679, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. R. W. Alberca-Custódio, F. R. Greiffo, B. MacKenzie et al., “Aerobic exercise reduces asthma phenotype by modulation of the leukotriene pathway,” Frontiers in Immunology, vol. 7, p. 237, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. R. P. Vieira, A. C. de Toledo, S. C. Ferreira et al., “Airway epithelium mediates the anti-inflammatory effects of exercise on asthma,” Respiratory Physiology & Neurobiology, vol. 175, pp. 383–389, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. R. T. Nesi, P. S. de Souza, G. P. Dos Santos et al., “Physical exercise is effective in preventing cigarette smoke-induced response in mice,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 22, no. 11, pp. 603–610, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Foronjy and J. D’armiento, “The effect of cigarette smoke–derived oxidants on the inflammatory response of the lung,” Clinical and Applied Immunology Reviews, vol. 6, pp. 53–72, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. Barnes, “Inflammatory mechanisms in patients with chronic obstructive pulmonary disease,” The Journal of Allergy and Clinical Immunology, vol. 138, no. 1, pp. 16–27, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. J. X. Jiang, S. J. Zhang, H. J. Shen et al., “Rac1 signaling regulates cigarette smoke-induced inflammation in the lung via the Erk1/2 MAPK and STAT3 pathways,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1863, no. 7, pp. 1778–1788, 2017. View at Publisher · View at Google Scholar
  15. J. Corren, “Inflammatory disorders associated with allergy: overview of immunopathogenesis and implications for treatment,” Immunology and Allergy Clinics of North America, vol. 37, no. 2, pp. 233–246, 2017. View at Publisher · View at Google Scholar
  16. Y. Wang, M. Jia, X. Yan et al., “Increased neutrophil gelatinase-associated lipocalin (NGAL) promotes airway remodelling in chronic obstructive pulmonary disease,” Clinical Science, vol. 131, no. 11, pp. 1147–1159, 2017. View at Publisher · View at Google Scholar
  17. L. I. Kunz, N. H. Ten Hacken, T. S. Lapperre et al., “Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids,” The European Respiratory Journal, vol. 49, no. 1, 2017. View at Publisher · View at Google Scholar
  18. H. Forsslund, M. Yang, M. Mikko et al., “Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 12, pp. 35–48, 2016. View at Publisher · View at Google Scholar
  19. S. S. Valenca, F. S. Bezerra, B. Romana-Souza, R. O. Paiva, A. M. Costa, and L. C. Porto, “Supplementation with vitamins C and E improves mice lung repair,” The Journal of Nutritional Biochemistry, vol. 19, pp. 604–611, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Kirkham and I. Rahman, “Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy,” Pharmacology & Therapeutics, vol. 111, pp. 476–494, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. A. M. Sadowska, B. M. Keenoy, and W. A. Backer, “Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose effects: a review,” Pulmonary Pharmacology & Therapeutics, vol. 20, pp. 9–22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Lahham, C. F. McDonald, and A. E. Holland, “Exercise training alone or with the addition of activity counseling improves physical activity levels in COPD: a systematic review and meta-analysis of randomized controlled trials,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 11, pp. 3121–3136, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. N. P. Walsh, M. Gleeson, R. J. Shephard et al., “Position statement. Part one: immune function and exercise,” Exercise Immunology Review, vol. 17, pp. 6–63, 2011. View at Google Scholar
  24. B. Celli, R. Goldstein, J. Jardim, and K. Knobil, “Future perspectives in COPD,” Respiratory Medicine, vol. 99, Supplement B, pp. S41–S48, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. R. S. Ahima and H. K. Park, “Connecting myokines and metabolism,” Endocrinology and Metabolism, vol. 30, no. 3, pp. 235–245, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Greulich, K. Kehr, C. Nell et al., “A randomized clinical trial to assess the influence of a three months training program (gym-based individualized vs. calisthenics-based non-individualized) in COPD-patients,” Respiratory Research, vol. 15, p. 36, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Karstoft and B. K. Pedersen, “Skeletal muscle as a gene regulatory endocrine organ,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 19, no. 4, pp. 270–275, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. A. P. Lightfoot and R. G. Cooper, “The role of myokines in muscle health and disease,” Current Opinion in Rheumatology, vol. 28, no. 6, pp. 661–666, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Ley, “Arrest chemokines,” Microcirculation, vol. 10, no. 3-4, pp. 289–295, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Kuwano, M. Adler, H. Zhang, A. Groisman, and K. Ley, “Gαi2 and Gαi3 differentially regulate arrest from flow and chemotaxis in mouse neutrophils,” Journal of Immunology, vol. 196, no. 9, pp. 3828–3833, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Wolach, R. Gavrieli, S. G. Ben-Dror, L. Zigel, A. Eliakim, and B. Falk, “Transient decrease of neutrophil chemotaxis following aerobic exercise,” Medicine and Science in Sports and Exercise, vol. 37, no. 6, pp. 949–954, 2005. View at Google Scholar
  32. W. Huan, Z. Tianzhu, L. Yu, and W. Shumin, “Effects of ergosterol on COPD in mice via JAK3/STAT3/NF-κB pathway,” Inflammation, vol. 1, 2017. View at Publisher · View at Google Scholar
  33. M. Emami Ardestani and O. Zaerin, “Role of serum iInterleukin 6, albumin and c-reactive protein in COPD patients,” Tanaffos, vol. 14, no. 2, pp. 134–140, 2015. View at Google Scholar
  34. S. M. Ruwanpura, L. McLeod, A. Miller et al., “Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice,” American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 302, no. 7, pp. L627–L639, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. S. M. Ruwanpura, L. McLeod, A. Miller et al., “Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice,” American Journal of Respiratory Cell and Molecular Biology, vol. 45, no. 4, pp. 720–730, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Kimura and T. Kishimoto, “IL-6: regulator of Treg/Th17 balance,” European Journal of Immunology, vol. 40, no. 7, pp. 1830–1835, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. M. J. McGeachy and D. J. Cua, “The link between IL-23 and Th17 cell-mediated immune pathologies,” Seminars in Immunology, vol. 19, no. 6, pp. 372–376, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Ruwanpura, L. McLeod, G. D. Brooks et al., “IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice,” Respirology, vol. 19, no. 3, pp. 419–427, 2014. View at Publisher · View at Google Scholar · View at Scopus