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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 6593073, 14 pages
https://doi.org/10.1155/2017/6593073
Research Article

Spondias purpurea L. (Anacardiaceae): Antioxidant and Antiulcer Activities of the Leaf Hexane Extract

1Postgraduate Program of Pharmaceutical Sciences, Universidade Federal de Pernambuco, Recife, PE, Brazil
2Department of Antibiotics, Universidade Federal de Pernambuco, Recife, PE, Brazil
3Department of Biochemistry, Universidade Federal de Pernambuco, Recife, PE, Brazil
4Department of Biological Sciences, Universidade Regional do Cariri, Crato, CE, Brazil
5Analytical Center of Drugs, Medicines and Food, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brazil
6Department of Pharmaceutical Sciences, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil
7Department of Physiology and Pharmacology, Universidade Federal de Pernambuco, Recife, PE, Brazil

Correspondence should be addressed to Teresinha Gonçalves da Silva; moc.liamg@001ahniseret

Received 21 May 2017; Revised 6 September 2017; Accepted 28 September 2017; Published 26 October 2017

Academic Editor: Francesca Danesi

Copyright © 2017 Cynthia Layse Ferreira de Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Spondias purpurea is used in folk medicine to treat diarrhea and diuresis. The objective of this study was to evaluate the phytochemical profile and antioxidant and antiulcer activities of the hexane extract of the leaves of S. purpurea (SpHE). Phytochemical profile was evaluated via thin layer chromatography (TLC) and HPLC. SpHE was screened for antioxidant activities using DPPH, ABTS, FRAP, and phosphomolybdenum assays. To determine its antiulcer properties, animals were pretreated with injured control, lansoprazole, ranitidine, carbenoxolone, or SpHE (12.5, 25, and 50 mg/kg) and were screened; acute ulcers were induced by HCl/ethanol, absolute ethanol, and nonsteroidal anti-inflammatory drug (NSAID). TLC revealed the presence of flavonoids, whereas HPLC analysis showed the presence of caffeic acid and epigallocatechin. The phenolic compounds and in vitro assays showed antioxidant activity. After gastric ulcer induction by using HCl/ethanol, SpHE reduced the area of ulcerative lesions by 82, 91, and 88%, respectively. In ethanol, SpHE reduced the area of ulcerative lesions by 77, 93, and 92%, respectively. In the NSAID, the percentages of protection were 70, 76, and 78%, respectively. SpHE promoted the minimization of ulcers, increased the levels of reduced glutathione, and decreased tumor necrosis factor. S. purpurea has antioxidant and antiulcer properties.