Spondias purpurea L. (Anacardiaceae): Antioxidant and Antiulcer Activities of the Leaf Hexane Extract

Figure 10

Histological analysis of the gastric mucosa of animals submitted to the induction of ulcer with NSAID (indomethacin). Animals were pretreated with 1% Tween 80 aqueous solution: injured control (a), ranitidine (b), and SpHE 12.5 mg/kg (c), 25 mg/kg (d), and 50 mg/kg (e). Observed in (a): disorganization of the gastric glands (arrows) and of the columnar simple epithelium in the gastric pits (enlarged detail, arrowhead) with cellular necrosis (dashed arrow); in (b): columnar simple epithelium of the pits (enlarged detail) and well-preserved gastric glands (arrows); in (c): gastric mucosa with slight exfoliations of the columnar simple epithelium and unpreserved gastric mucosa (asterisk); in (d): preserved gastric mucosa (asterisk) with exfoliations of discrete columnar epithelium (enlarged detail, arrow); and in (e): preserved gastric mucosa (asterisk) and simple columnar simple epithelium (enlarged detail).

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