Spondias purpurea L. (Anacardiaceae): Antioxidant and Antiulcer Activities of the Leaf Hexane Extract

Figure 8

Histological analysis of the gastric mucosa of animals submitted to the induction of ulcer with HCl/ethanol. Animals were pretreated with 1% Tween 80 aqueous solution: injured control (a), lansoprazole (b), and SpHE 12.5 mg/kg (c), 25 mg/kg (d), and 50 mg/kg (e). Observed in (a): evidence of disorganization of the columnar simple epithelium in the gastric pits (enlarged detail, arrowhead) and gastric glands (arrows), congestion of the blood capillaries (enlarged detail, asterisk), and necrosis of the gastric mucosa cells (enlarged detail); in (b): preserved columnar simple epithelium in the gastric pits (enlarged detail) and well-preserved gastric glands (arrow); in (c): nonpreserved gastric mucosa with exfoliation of the simple columnar epithelium (enlarged detail); in (d): gastric mucosa with slight focal exfoliations of the simple columnar epithelium and preserved gastric mucosa (asterisk); and in (e): preserved gastric mucosa and simple columnar epithelium (enlarged detail).

(a)

(b)

(c)

(d)

(e)