|
| Study (year) | Journal | Country | Inclusion/exclusion criteria | Patient number | Short-term outcome | Long-term outcome |
|
| Leclerc et al. (2015) [12] | Proceedings of the National Academy of Sciences of the United States of America | USA | Inclusion: >18 years, aSAH | Hp 1-1: 11 | Clinical deterioration as a consequence of confirmed delayed cerebral ischemia | — |
| Hp 2-1: 39 |
| Hp 2-2: 24 |
| Murthy et al. (2016) [13] | Neurosurgery | USA | Inclusion: >18 years, aSAH presenting within 24 h of ictus
Exclusion: death on arrival, pregnancy, inability to obtain consent | Hp 1-1: 29 | Delayed cerebral ischemia defined as clinical deterioration with radiographic, angiographic or clinical response to treatment with TCD evidence | GOS at 30 days post discharge |
| Hp 2-1: 57 |
| Hp 2-2: 47 |
| Kantor et al. (2014) [6] | Journal of Neurosurgery | USA | Inclusion: 18–75 years, angiographic diagnosis of aSAH, Fisher grade 2–4, Caucasian
Exclusion: pre-existing neurological disease or deficit | Hp 1-1: 25 | — | mRS at 3 months |
| Hp 2-1: 109 |
| Hp 2-2: 59 |
| Ohnishi et al. (2013) [14] | Journal of Stroke and Cerebrovascular Diseases | Japan | Inclusion: aSAH treated endovascularly or surgically | Hp 1-1: 7 | Delayed cerebral ischemia defined as development of focal neurology of a drop in GCS of 2 points | mRS at 3 months |
| Hp 2-1: 39 |
| Hp 2-2: 49 |
| Galea et al. (2012) [8] | Journal of Neurochemistry | UK | Inclusion: SAH requiring external ventricular drainage, paired CSF and serum available
Exclusion: external ventricular drain infection | Hp 1-1: 4 | Delayed cerebral ischemia defined as development of focal neurology of a drop in GCS of 2 points | — |
| Hp 2-1: 21 |
| Hp 2-2: 1 |
| Borsody et al. (2006) [11] | Neurology | USA | Inclusion: >18 years, known date onset SAH, aSAH suspected, Fisher grade 3-4
Exclusion: diseases which affect Hp or development of VS | Hp 1-1: 9 | Transcranial Doppler (TCD) evidence of “presumed definite” vasospasm or angiogram evidence of vasospasm both by day 14 after SAH | — |
| Hp 2-1: 12 |
| Hp 2-2: 11 |
|
