Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 2

Research Article

Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis

Table 2

Summary of studies included in meta-analysis.

Study (year)JournalCountryInclusion/exclusion criteriaPatient numberShort-term outcomeLong-term outcome

Leclerc et al. (2015) [12]Proceedings of the National Academy of Sciences of the United States of AmericaUSAInclusion: >18 years, aSAHHp 1-1: 11Clinical deterioration as a consequence of confirmed delayed cerebral ischemia
Hp 2-1: 39
Hp 2-2: 24
Murthy et al. (2016) [13]NeurosurgeryUSAInclusion: >18 years, aSAH presenting within 24 h of ictus
Exclusion: death on arrival, pregnancy, inability to obtain consent
Hp 1-1: 29Delayed cerebral ischemia defined as clinical deterioration with radiographic, angiographic or clinical response to treatment with TCD evidenceGOS at 30 days post discharge
Hp 2-1: 57
Hp 2-2: 47
Kantor et al. (2014) [6]Journal of NeurosurgeryUSAInclusion: 18–75 years, angiographic diagnosis of aSAH, Fisher grade 2–4, Caucasian
Exclusion: pre-existing neurological disease or deficit
Hp 1-1: 25mRS at 3 months
Hp 2-1: 109
Hp 2-2: 59
Ohnishi et al. (2013) [14]Journal of Stroke and Cerebrovascular DiseasesJapanInclusion: aSAH treated endovascularly or surgicallyHp 1-1: 7Delayed cerebral ischemia defined as development of focal neurology of a drop in GCS of 2 pointsmRS at 3 months
Hp 2-1: 39
Hp 2-2: 49
Galea et al. (2012) [8]Journal of NeurochemistryUKInclusion: SAH requiring external ventricular drainage, paired CSF and serum available
Exclusion: external ventricular drain infection
Hp 1-1: 4Delayed cerebral ischemia defined as development of focal neurology of a drop in GCS of 2 points
Hp 2-1: 21
Hp 2-2: 1
Borsody et al. (2006) [11]NeurologyUSAInclusion: >18 years, known date onset SAH, aSAH suspected, Fisher grade 3-4
Exclusion: diseases which affect Hp or development of VS
Hp 1-1: 9Transcranial Doppler (TCD) evidence of “presumed definite” vasospasm or angiogram evidence of vasospasm both by day 14 after SAH
Hp 2-1: 12
Hp 2-2: 11

Only outcomes which were available for the meta-analysis are shown.

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