Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

Figure 4

Fucoxanthin attenuates Aβ oligomer-induced increase of intracellular ROS level as evidenced by carboxy-H₂DCF-DA staining. SH-SY5Y cells were treated with 3 μM fucoxanthin. After 2 h, 1 μM Aβ oligomer was added. Carboxy-H₂DCF-DA staining was used to measure intracellular ROS level at 24 h after the treatment of Aβ oligomers. Data were the mean ± SEM of three separate experiments; ^# versus the control group; versus the Aβ oligomer group (ANOVA and Tukey’s test).