Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

Figure 5

Aβ oligomers inhibit the PI3K/Akt pathway and activate the ERK pathway in SH-SY5Y cells. SH-SY5Y cells were treated with 1 μM Aβ oligomer for various durations as indicated. Western blotting analysis was used to determine the expression of (a) pSer473-Akt, (b) pSer9-GSK3β, and (c) pERK. Data were the mean ± SEM of three separate experiments; and versus the control group (ANOVA and Tukey’s test).

(a)

(b)

(c)