Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

Figure 7

Fucoxanthin prevents Aβ oligomer-induced alteration of the PI3K/Akt and the ERK pathways in a concentration-dependent manner in SH-SY5Y cells. SH-SY5Y cells were treated with 1 or 3 μM fucoxanthin. After 2 h, 1 μM Aβ oligomer was added. Western blotting analysis was used to determine the expression of (a) pSer473-Akt, (b) pSer9-GSK3β, and (c) pERK at 6 h after the treatment of Aβ oligomers. Data were the mean ± SEM of three separate experiments; ^## versus the control group; and versus the Aβ oligomer group (ANOVA and Tukey’s test).

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