Research Article
Antioxidant Treatment Reduces Formation of Structural Cores and Improves Muscle Function in RYR1Y522S/WT Mice
Figure 3
In vivo grip strength and ex vivo specific force at 4 months of age. (a) Time-course of grip strength from 2 (beginning of short-term NAC treatment) to 4 months (end of short-term NAC treatment) of age expressed as force on body weight (N/g). (b) Change in grip strength from 2 to 4 months of age (shown as a percentage). (c and d) Force-frequency (1–140 Hz) relationship curves of specific force (c) and specific force during a single 2 s, 120 Hz stimulation train (d) recorded for the same EDL muscles. Data are given as mean ± SEM; , WT versus RYR1Y522S/WT mice; #, untreated RYR1Y522S/WT versus NAC-treated RYR1Y522S/WT mice. In (b), n = number of mice; in (d), n = number of EDL muscles.
| (a) |
| (b) |
| (c) |
| (d) |