Antioxidant Treatment Reduces Formation of Structural Cores and Improves Muscle Function in RYR1^Y522S/WT Mice

Figure 6

Oxidative stress markers at 4 and 10 months of age following either short- or long-term treatment. (a and e) Representative immunoblots showing expression of 3-Nitrotyrosine (3-NT), SOD1, and SOD2 in total hind limb muscle homogenates. (b–d) and (f–h) Relative band densities normalized to GAPDH levels. Data are given as mean ± SEM; , WT versus RYR1^Y522S/WT mice; ^#, untreated RYR1^Y522S/WT versus NAC-treated RYR1^Y522S/WT mice. n = number of mice.