Oxidative Medicine and Cellular Longevity / 2017 / Article / Fig 6

Research Article

Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis

Figure 6

Effect of edaravone on alteplase-induced fibrinolysis in PPP. (a) Effects of alteplase (50, 100, or 250 IU/ml) in pooled platelet-poor plasma (). Error bars represent standard deviation. (b) Effects of edaravone (6 or 60 nM), alteplase (100 IU/ml), or their combination on alteplase-induced thrombolysis in pooled PPP (). Error bars represent standard deviation. (c) Measurement of D-dimer concentration to evaluate effects of edaravone (60 nM) on H2O2 (100 μM)-inhibited fibrinolysis by alteplase (100 IU/ml) in pooled PPP (). Error bars represent standard deviation. PPP: platelet-poor plasma; H2O2: hydrogen peroxide.

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