Histopathological Changes in the Kidney following Congestive Heart Failure by Volume Overload in Rats

Figure 7

Transmission electron micrograph of the rat kidney in control (a) and ACF (b and c) groups. (a) shows normal ultrastructure of the control kidney. Note; untreated control of kidney cells consist of vital nucleus (N), well-developed cell organelles like mitochondria (M), lysosome (L), and a well-organized cytoplasm. (b) Electron microscopic demonstration of the ACF kidney tissue. Note that ultrastructure evaluations show a marked cytoplasmic vacuolization (V) of cells and capillary (C) dilation in the peritubular area and dilated cell organelles and cell nuclei (N) became condensed indicating intrinsic apoptotic events. (c) Many swollen mitochondria situated between the extensive inholdings (arrow) of the basolateral plasma membrane () that create the lateral cell processes of distal tubules become dilated and exhibit a crista disarrangement and partial cristolysis. ×5000; bars:1 μm.

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