Heme Oxygenase-1, a Key Enzyme for the Cytoprotective Actions of Halophenols by Upregulating Nrf2 Expression via Activating Erk1/2 and PI3K/Akt in EA.hy926 Cells

Figure 8

Mediation of HP3 on MAPK, PI3K/Akt, and PKC signaling pathways. (a) HP3 induced Erk1/2 phosphorylation in a concentration-dependent manner. (b) HP3 induced Akt phosphorylation in a concentration-dependent manner. (c) HP3 had no influence on p38 phosphorylation. (d) HP3 had no influence on JNK phosphorylation. (e) HP3 had no influence on PKC-δ protein expression. (f) Influences of the inhibitors PD98059 and Wortmannin on HO-1 expression. The uses of inhibitors significantly reduced HO-1 expression compared to those of treatment with HP3 alone. .

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