Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-κB-Dependent Autophagy

Figure 10

Picroside II reduced the deacetylation of endogenous LC3 by upregulating the level of SIRT1. Picroside II reduced the level of TNF-α by reducing the level NF-κB, which deacetylated LC3. The acetylated LC3 was detected by using an IP test and Western blot. +, picroside II treatment. −, without picroside II treatment. via the picroside II-treated group.