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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 7120962, 13 pages
Review Article

The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine

1Department of Surgery, University Medical Center Groningen, Groningen, Netherlands
2Department of Digestive Surgery, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
3Laboratory of Abdominal Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
4Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
5Laboratory of Pediatrics, University Hospitals Leuven, Leuven, Belgium

Correspondence should be addressed to Jean-Paul Decuypere; eb.nevueluk@erepyuced.luapnaej

Received 28 July 2017; Revised 21 September 2017; Accepted 8 October 2017; Published 19 December 2017

Academic Editor: Maria C. Albertini

Copyright © 2017 Anne C. Van Erp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many factors during the transplantation process influence posttransplant graft function and survival, including donor type and age, graft preservation methods (cold storage, machine perfusion), and ischemia-reperfusion injury. Successively, they will lead to cellular and molecular alterations that determine cell and ultimately organ fate. Oxidative stress and autophagy are implicated in posttransplant outcome since they are both affected by the stress responses triggered in each step (donor, preservation, and recipient) of the transplantation process. Furthermore, oxidative stress influences autophagy and vice versa. Interestingly, both processes have positive as well as negative effects on graft outcome, suggesting they are tightly linked during the transplantation process. In this review, we discuss the importance, regulation and crosstalk of oxidative signals, and autophagy in the field of transplantation medicine.